As I've already discussed with some people on Slack, we are making a portable console prototype which will support PICO-8 games:
I'm doing this with the developer of Lakka and he is currently adapting the picolove implementation to run on this console. As we use RetroArch under the hood, that means this PICO-8 loader could potentially be available on a lot of hardware (Raspberry Pi, ODROID, Android, etc.)
As our screen is 320x240 we think of giving the user the option of running PICO-8 games at either 128x128 or 256x240 with neighbor interpolation.
What do you think?